Leftover Turkey Cranberry Sandwich

Highlight: Satisfying Main Dishes for Every Occasion

This sandwich layers tender slices of leftover turkey with tangy cranberry sauce, fresh green leaf lettuce, and creamy herbed mayo. Spread on nutty bread and topped with cheese, it offers a perfect balance of textures and flavors. With just a quick prep time, it transforms holiday leftovers into a delicious and filling dish that’s great for any day after the big feast. Simple ingredients come together for a fresh and comforting bite.

A woman in a blue apron holding a plate of food.
Crafted By Sophie
Updated on Sat, 06 Dec 2025 19:34:50 GMT
A sandwich with cranberry sauce and turkey. Save
A sandwich with cranberry sauce and turkey. | myhomemademeal.com

This Leftover Cranberry Turkey Sandwich is the perfect way to enjoy the day after Thanksgiving without any extra cooking. With nutty bread, a herbed mayo spread, crisp lettuce, savory turkey slices, melting cheese, and sweet cranberry sauce, it captures all the flavors of the holiday in a simple handheld meal. It makes use of leftovers in a way that feels fresh and satisfying.

I first made this the morning after Thanksgiving when my fridge was full and no one wanted to cook, and now it’s a family tradition everyone looks forward to.

Ingredients

  • Two slices of nutty bread: choose a hearty bread like multigrain or whole wheat for texture and flavor
  • Three tablespoons mayonnaise: this forms a creamy base for the herbed spread
  • Pinch of poultry seasoning: this adds a subtle savory touch that ties the sandwich to turkey
  • Salt and pepper: season to taste to enhance all the flavors
  • One tablespoon chopped chives: fresh chives add a mild onion flavor and a hint of color
  • Green leaf lettuce: for crunch and brightness, pick fresh crisp leaves
  • Half a pound of sliced leftover turkey: thick slices will keep the sandwich hearty and satisfying
  • Quarter cup cranberry sauce: the sweet-tart sauce is essential for that classic Thanksgiving flavor contrast

Step-by-Step Instructions

Scoop and Mix the Herbed Mayo:
In a small bowl, combine mayonnaise with the pinch of poultry seasoning, salt, pepper, and chopped chives. Stir until well blended to create a flavorful spread.
Spread the Mayo on the Bread:
Take the two slices of nutty bread and generously spread the herbed mayo on both pieces. This will add moisture and extra flavor to every bite.
Layer the Sandwich:
On one slice of bread, arrange a piece of cheese (optional but recommended), then add a layer of green leaf lettuce. Follow with thick slices of leftover turkey, then spoon cranberry sauce evenly over the top.
Close and Serve:
Place the second slice of bread on top to complete your sandwich. Cut it in half if you like, which makes it easier to handle and share. Serve immediately for the best texture.
A stack of sandwiches with cranberry sauce and turkey. Save
A stack of sandwiches with cranberry sauce and turkey. | myhomemademeal.com

Storage Tips

If you have leftovers, wrap the sandwich tightly in plastic wrap or place it in an airtight container and refrigerate. It’s best eaten the same day but can keep for up to 24 hours. Avoid adding lettuce before storing to prevent sogginess.

Ingredient Substitutions

  • Swap nutty bread for a soft brioche bun or a sturdy ciabatta roll if you prefer a different texture
  • Use Greek yogurt mixed with mayonnaise if you want a lighter herbed spread
  • Fresh rosemary or thyme can replace poultry seasoning if you want a herb twist

Serving Suggestions

  • Pair the sandwich with a simple side salad of mixed greens and a balsamic vinaigrette to keep things fresh
  • Homemade sweet potato chips or classic kettle-cooked chips also make a great crunchy side

Pro Tips

  • Toast the bread lightly for extra crunch and to help prevent sogginess from the cranberry sauce
  • Use thick slices of turkey for a more satisfying bite that holds together well
  • Don’t skip the fresh chives in the mayo, they add a surprising burst of brightness that lifts the sandwich

Recipe FAQs

→ What type of bread works best for this sandwich?

Nutty or whole grain bread adds a hearty texture and nutty flavor that complements turkey and cranberry beautifully.

→ Can I prepare the herbed mayo in advance?

Yes, mixing mayo with poultry seasoning, chives, salt, and pepper ahead of time lets flavors meld nicely before assembling.

→ How should leftover turkey be sliced for this sandwich?

Thick, even slices of turkey provide a satisfying bite and maintain moisture when layered with cranberry sauce.

→ Is there a suggested cheese to include?

Mild cheeses like Swiss or Havarti work well, adding creaminess without overpowering other flavors.

→ What is the best way to serve this sandwich?

Cut in half and serve immediately to enjoy the contrast of textures from the crunchy bread and tender fillings.

Leftover Turkey Cranberry Sandwich

Hearty turkey and cranberry sandwich on nutty bread with herbed mayo and crisp lettuce for a satisfying meal.

Prep Time
5 minutes
Cooking Duration
~
Overall Time
5 minutes
Crafted By: Sophie

Recipe Type: Main Dishes

Preparation Complexity: Beginner-Friendly

Regional Cuisine: American

Servings Output: 1 Serving Size (1 sandwich)

Dietary Choices: ~

Everything You’ll Need

→ Bread

01 2 slices nutty bread

→ Spread

02 3 tablespoons mayonnaise
03 Pinch poultry seasoning
04 Salt to taste
05 Black pepper to taste
06 1 tablespoon chopped chives

→ Filling

07 1/2 pound sliced leftover turkey
08 1/4 cup cranberry sauce
09 Green leaf lettuce leaves

Steps to Cook

Step 01

Combine mayonnaise, poultry seasoning, chopped chives, salt, and pepper in a small bowl; mix thoroughly.

Step 02

Spread the herbed mayonnaise evenly onto both slices of nutty bread.

Step 03

On one slice of bread, layer lettuce, sliced leftover turkey, and cranberry sauce in that order.

Step 04

Place the second slice of bread on top to close the sandwich, cut in half, and serve immediately.

Extra Suggestions

  1. Use chilled leftover turkey for optimal texture and flavor.

Must-Have Equipment

  • Cutting board
  • Sharp knife
  • Mixing bowl

Allergy Information

Always check ingredient details for potential allergens. Consult an expert if you're uncertain.
  • Contains eggs and wheat; may contain dairy depending on bread and mayonnaise brands.

Nutritional Highlights (per portion)

Nutritional information is shared for guidance and isn't meant to replace expert medical advice.
  • Caloric Content: 997
  • Fat Breakdown: 50 grams
  • Carbohydrate Breakdown: 62 grams
  • Protein Count: 72 grams