Mac Cheese Meatloaf Casserole

This mac and cheese meatloaf casserole combines two beloved comfort foods into one extraordinary dish that will satisfy even the pickiest eaters in your family. The savory meatloaf base provides the perfect foundation for creamy mac and cheese topping, creating a meal that's both hearty and comforting.

I created this recipe during a particularly busy week when I needed something that would please everyone at the table. My children now request this "ultimate comfort food mashup" almost weekly, and I'm happy to oblige since it's so simple to prepare.

Ingredients

• Ground beef creates the hearty foundation. Choose 80/20 for best flavor and moisture
• Breadcrumbs help bind the meatloaf. Fresh work best but panko are excellent too
• Milk adds moisture to the meatloaf mixture ensuring it stays tender
• Egg acts as the essential binder that holds everything together
• Onion and garlic provide aromatic flavor to the meat base. Mince them finely for best texture
• Worcestershire sauce adds that umami depth that makes meatloaf irresistible
• Ketchup brings tangy sweetness to balance the savory elements
• Elbow macaroni works perfectly for the cheese sauce. Cook just until al dente
• Butter and flour create the roux that thickens your cheese sauce beautifully
• Whole milk makes the creamiest mac and cheese. Avoid skim for best results
• Cheddar cheese is the star. Use sharp for maximum flavor impact
• Mustard powder enhances the cheese flavor without adding actual mustard taste

Step-by-Step Instructions

Preheat the Oven

Set your oven to 350°F while preparing the ingredients. This moderate temperature allows both components to cook evenly without burning the cheese topping. A properly preheated oven ensures even cooking throughout.

Prepare the Meatloaf Base

Combine all meatloaf ingredients in a large bowl. Use your hands to mix gently until just combined. Overmixing will result in a tough meatloaf. Press the mixture firmly but gently into your baking dish, creating an even layer that will cook uniformly.

Bake the Meatloaf Base

Partially bake the meatloaf for 15 minutes. This initial cooking period sets the meat mixture and starts developing flavor while you prepare the mac and cheese. The meatloaf will finish cooking when the entire casserole returns to the oven.

Prepare the Mac and Cheese

Create a smooth roux by cooking butter and flour together until it smells slightly nutty but hasn't browned. Slowly incorporate milk, whisking constantly to prevent lumps. Allow the sauce to thicken until it coats the back of a spoon before adding cheese. Fold in cooked pasta, ensuring every piece is coated with the velvety sauce.

Assemble the Casserole

Layer the creamy mac and cheese over the partially baked meatloaf base. Distribute it evenly, pushing slightly to the edges. Add an extra handful of cheese on top which will create an irresistible golden crust during the final baking.

Bake the Casserole

Return the assembled casserole to the oven for its final bake. The cheese will bubble and become golden while the flavors meld together. The internal temperature should reach 160°F to ensure the meatloaf is fully cooked.

Serve

Allow the casserole to rest briefly before serving. This resting period helps the casserole set up for easier cutting and serving. The flavors also continue to develop during this time.

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The secret to this recipe's success is the sharp cheddar cheese. I once tried to substitute a milder cheese and my family immediately noticed the difference. The pronounced flavor of aged cheddar stands up beautifully against the savory meatloaf base, creating that perfect balance that makes this dish so special.

Make Ahead Tips

This casserole is perfect for meal prep. Prepare the entire dish up to the final baking step, cover tightly with foil, and refrigerate for up to 24 hours. When ready to serve, bake as directed, adding about 10 minutes to the cooking time since you're starting with a cold dish. The texture and flavor remain perfect, making this an ideal option for busy weeknights or when entertaining guests.

Creative Variations

While the classic recipe is always a hit, there are countless ways to customize this casserole. Try Italian style by adding Italian seasoning to the meatloaf and using mozzarella in the mac and cheese. For a Mexican twist, incorporate taco seasoning into the meat and add diced peppers and pepper jack cheese to the pasta. During autumn, I love adding a layer of roasted butternut squash between the meatloaf and mac and cheese for a seasonal touch that adds beautiful color and nutrition.

Serving Suggestions

Balance this rich casserole with lighter side dishes. A crisp green salad dressed with vinaigrette provides refreshing contrast. Steamed broccoli or green beans add color and nutrition. For casual gatherings, serve with garlic bread to soak up any extra cheese sauce. This casserole holds its heat well, making it perfect for potlucks or family dinners where people may serve themselves at different times.

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Recipe FAQs

→ Can I make this casserole ahead of time?

Yes, you can assemble the entire casserole up to 24 hours ahead and refrigerate covered. Add 10-15 minutes to the final baking time if cooking from cold. You can also fully cook it, refrigerate, and reheat covered with foil at 325°F until warmed through.

→ What can I substitute for ground beef?

Ground turkey, chicken, or pork work well as alternatives. For a vegetarian version, try using a plant-based ground meat substitute or a hearty mixture of finely chopped mushrooms, walnuts, and lentils.

→ Can I use boxed mac and cheese instead of making it from scratch?

Yes, prepared boxed mac and cheese can be used as a time-saving alternative. For best results, make it slightly creamier than package directions since it will continue cooking in the oven.

→ How do I know when the casserole is done baking?

The casserole is done when the cheese topping is bubbly and golden brown, and the internal temperature reaches 160°F. The edges should be slightly crispy, and the center should be set but still moist.

→ What sides pair well with this casserole?

This hearty dish pairs perfectly with lighter sides like a crisp green salad, steamed broccoli, roasted vegetables, or garlic bread. The freshness balances the richness of the casserole.

→ Can I freeze leftovers?

Yes, leftovers freeze well for up to 3 months. Portion into airtight containers, cool completely before freezing, and thaw overnight in the refrigerator before reheating until hot throughout.