Easy Chicken Cheesy Pasta

Highlight: Satisfying Main Dishes for Every Occasion

This dish layers tender, seasoned chicken with a creamy cheese sauce and perfectly cooked pasta. The addition of Cajun spices introduces a gentle kick, while garlic and Parmesan deepen the flavors. After sautéing and mixing all components, it’s baked until golden and bubbly, creating a comforting, hearty meal that’s ideal for family dinners or gatherings. With simple steps and ingredients, it brings warmth and rich taste to the table without fuss.

Luna chef wearing a white shirt.
Crafted By Luna
Updated on Sun, 04 Jan 2026 20:37:35 GMT
A plate of food with chicken and pasta. Save
A plate of food with chicken and pasta. | myhomemademeal.com

This creamy Cajun chicken pasta bake is the kind of dinner that turns an ordinary night into a cozy occasion. The tender chicken melds beautifully with the cheesy sauce, while the Cajun seasoning adds a friendly kick that makes every bite exciting. It’s ideal for family dinners or sharing with friends when you want to impress without stress.

I first made this dish on a chilly evening when I wanted something hearty but fuss-free. Now it’s a favorite that everyone asks for because it tastes both indulgent and homey.

Ingredients

  • Chicken breasts: about one and a half pounds of boneless skinless chicken that stay juicy when cooked
  • Pasta: choose penne or rotini for their ability to hold sauce well and provide a pleasant texture
  • Cream cheese: full-fat version gives the sauce its rich and velvety texture
  • Cajun seasoning: brings a flavorful spicy warmth, adjust according to your taste preference
  • Fresh garlic: minced for an aromatic base that enhances all other flavors
  • Low-sodium chicken broth: adds moisture and depth without being too salty
  • Grated Parmesan cheese: adds a sharp savory note that melts into the sauce
  • Olive oil: used to sauté the chicken and garlic gently without burning
  • Salt and pepper: to season according to your preference, essential to balance flavors

Step-by-Step Instructions

Preheat the Oven:
Preheat your oven to 375 degrees Fahrenheit or 190 degrees Celsius. Lightly grease a baking dish with nonstick spray to ensure your pasta bake doesn’t stick and helps with even browning.
Cook the Pasta:
Bring a large pot of salted water to a boil. Add the penne or rotini pasta and cook it until it reaches al dente—firm to the bite but not hard. Drain thoroughly and set aside to keep warm.
Sauté the Garlic and Chicken:
Heat olive oil in a large skillet over medium heat. When the oil shimmers, add the minced garlic and sauté for about one minute until fragrant but not browned. Season the chicken breasts with salt, pepper, and Cajun seasoning. Place them in the skillet and cook about six to seven minutes on each side until nicely golden and fully cooked inside.
Prepare the Creamy Sauce:
Reduce the heat to low. Add the cream cheese to the skillet with the cooked chicken along with chicken broth and extra Cajun seasoning if you like more spice. Stir continuously to create a smooth creamy sauce. Then blend in the grated Parmesan cheese until melted and well combined.
Combine and Bake:
Slice the cooked chicken into bite-sized pieces and toss them with the drained pasta in the creamy sauce directly in the skillet or a large bowl. Mix everything thoroughly so the pasta is well coated. Pour the mixture into the prepared baking dish. Bake for twenty to twenty-five minutes until it bubbles and the top is golden.
A plate of food with chicken and pasta. Save
A plate of food with chicken and pasta. | myhomemademeal.com

My favorite ingredient is the Cajun seasoning because it dramatically lifts the dish from simple to memorable. The first time I made this, my family’s surprised smiles convinced me this was going in our regular rotation.

Storage Tips

Store leftovers in an airtight container and keep in the refrigerator for up to three days. When reheating, cover with foil or a lid to retain moisture and avoid the pasta drying out. This bake also freezes nicely; just thaw overnight in the fridge before warming in the oven.

Ingredient Substitutions

If you can’t find Cajun seasoning, try mixing smoked paprika, garlic powder, onion powder, black pepper, and cayenne pepper to taste. Use whole milk cream cheese instead of full fat if you want a lighter option but the sauce might be less rich. Penne can be swapped with fusilli or macaroni depending on what you have on hand.

Serving Suggestions

Pair this pasta bake with a crisp green salad dressed lightly with lemon vinaigrette to balance the richness. Garlic bread or a simple side of steamed broccoli also complement the creamy texture and add freshness to the plate.

Pro Tips

  • Toast the Cajun seasoning in the pan before adding the other ingredients to unlock deeper flavors
  • Using room temperature cream cheese helps it melt smoothly without lumps in the sauce
  • Let the bake rest for about five minutes after removing it from the oven so it sets slightly and is easier to serve

Recipe FAQs

→ What type of pasta works best for this dish?

Penne or rotini are ideal as their shape holds the creamy sauce well, ensuring every bite is flavorful.

→ Can the chicken be substituted or omitted?

While chicken adds heartiness, you can swap it for turkey or a plant-based alternative to suit different preferences.

→ How spicy is the Cajun seasoning in this dish?

The Cajun seasoning provides a mild to moderate heat that complements the creamy cheese without overpowering the flavors. Adjust to your liking.

→ Is it necessary to bake the dish after mixing?

Baking melds the flavors and develops a bubbly, golden crust that enhances the texture and appearance of the dish.

→ Can this be prepared ahead of time?

Yes, you can assemble the layers in advance and refrigerate. Bake just before serving to enjoy the fresh bubbly finish.

Easy Chicken Cheesy Pasta

Tender chicken and cheesy pasta combined with Cajun spices for a warm, satisfying dinner.

Prep Time
15 minutes
Cooking Duration
30 minutes
Overall Time
45 minutes
Crafted By: Luna

Recipe Type: Main Dishes

Preparation Complexity: Beginner-Friendly

Regional Cuisine: Cajun

Servings Output: 6 Serving Size (Serves approximately 6)

Dietary Choices: ~

Everything You’ll Need

→ Protein

01 3 to 4 boneless, skinless chicken breasts (1.5 lbs)

→ Pasta

02 8 oz penne or rotini pasta

→ Dairy

03 8 oz full-fat cream cheese
04 ½ cup grated Parmesan cheese

→ Seasoning and Flavorings

05 2 tbsp Cajun seasoning (adjust to taste)
06 3 cloves fresh garlic, minced
07 Salt and black pepper to taste

→ Liquids

08 2 cups low-sodium chicken broth
09 2 tbsp olive oil

Steps to Cook

Step 01

Preheat oven to 375°F and grease a baking dish with nonstick spray.

Step 02

Boil pasta in salted water until al dente, then drain and set aside.

Step 03

Heat olive oil in a skillet over medium heat. Add minced garlic and cook until fragrant. Season chicken breasts with salt, pepper, and Cajun seasoning, then cook until golden brown on both sides, about 6-7 minutes per side.

Step 04

Reduce heat to low, add cream cheese, chicken broth, and additional Cajun seasoning to skillet. Stir until sauce is smooth, then incorporate grated Parmesan cheese.

Step 05

Slice cooked chicken into bite-size pieces and fold into sauce along with the cooked pasta until evenly coated.

Step 06

Transfer the mixture to the prepared baking dish and bake for 20 to 25 minutes until bubbly and golden on top.

Extra Suggestions

  1. For best results, avoid overcooking the pasta before baking to maintain optimal texture.

Must-Have Equipment

  • Oven
  • Baking dish
  • Skillet
  • Pot for boiling pasta

Allergy Information

Always check ingredient details for potential allergens. Consult an expert if you're uncertain.
  • Contains dairy and gluten

Nutritional Highlights (per portion)

Nutritional information is shared for guidance and isn't meant to replace expert medical advice.
  • Caloric Content: 540
  • Fat Breakdown: 22 grams
  • Carbohydrate Breakdown: 48 grams
  • Protein Count: 34 grams